INT29254

Context Info Confidence 0.13 First Reported 1988 Last Reported 1988 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.06 Pain Relevance 0.44

endosome (ADRA2C) extracellular space (GH1) extracellular region (GH1) small molecule metabolic process (ADRA2C) plasma membrane (ADRA2C) cell-cell signaling (ADRA2C)

ADRA2C (Homo sapiens) GH1 (Homo sapiens)

Pain Link Frequency Relevance Heat Clonidine 6 88.88

Disease Link Frequency Relevance Heat Hypoglycemia 1 56.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results suggest that while moderate activation of the alpha 2-adrenergic system stimulates GH release, further stimulation of the same system may result in inhibition, rather than further activation, of GH secretion.

Positive_regulation (activation) of alpha 2-adrenergic Positive_regulation (stimulates) of Localization (release) of GH

1) Confidence 0.13 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2826526 Disease Relevance 0.06 Pain Relevance 0.44

General Comments

This test has worked.