INT292750

Context Info Confidence 0.01 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.67 Pain Relevance 0.15

aging (Akt1, Bcl2) nucleus (Akt1, Bcl2) cytoplasm (Akt1, Bcl2) cytosol (Akt1, Bcl2) nucleoplasm (Akt1) mitochondrion (Bcl2)

Anatomy Link Frequency cardiac myocytes 1 Akt1 (Rattus norvegicus) Bcl2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat ischemia 18 88.72 Inflammation 18 43.60 depression 2 25.84 cytokine 6 9.76 cva 24 5.00 Inflammatory response 3 5.00 adenocard 2 5.00 Thoracotomy 2 5.00 Pain 1 5.00 medulla 1 5.00

Disease Link Frequency Relevance Heat Hypothermia 138 99.78 Hemorrhagic Shock 18 99.34 Apoptosis 9 96.04 Cv Unclassified Under Development 16 88.72 Stress 3 85.88 Death 9 84.80 Cv General 4 Under Development 1 57.04 Injury 61 50.00 Hemorrhage 46 50.00 Brain Injury 4 47.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In rodent model of hemorrhagic shock, profound hypothermia preserved Akt in cardiac myocytes, activated pro-survival proteins including Bcl-2 and beta catenin and suppressed Bad and caspase-3 activation [101].

Akt Positive_regulation (activated) of Bcl-2 in cardiac myocytes associated with hypothermia and hemorrhagic shock

1) Confidence 0.01 Published 2009 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2806855 Disease Relevance 1.67 Pain Relevance 0.15

General Comments

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