INT292955

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Context Info
Confidence 0.59
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.35
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fto) molecular_function (Fto) cellular_component (Fto)
Anatomy Link Frequency
hypothalamus 2
Fto (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aids-related Complex 90 99.68 Very High Very High Very High
Hyperphagia 2 98.06 Very High Very High Very High
Obesity 22 91.44 High High
Apoptosis 2 11.44 Low Low
Body Weight 10 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Viral Infection 2 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 2 5.00 Very Low Very Low Very Low
Appetite Loss 2 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fasting reduces levels of Fto mRNA in the arcuate nucleus (ARC) of the hypothalamus, a site where Fto expression is particularly high.
Negative_regulation (reduces) of Transcription (levels) of Fto in hypothalamus associated with aids-related complex
1) Confidence 0.59 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2808248 Disease Relevance 0.54 Pain Relevance 0
Our findings demonstrate that reduction in Fto expression selectively in the ARC results in increased food intake, a finding consistent with the hyperphagia seen in mice lacking Fto and congruent with the fact that fasting (a strong stimulus to eating) reduces Fto mRNA levels in the ARC [16].
Negative_regulation (reduces) of Transcription (levels) of Fto associated with hyperphagia and aids-related complex
2) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.81 Pain Relevance 0

General Comments

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