INT293105

Context Info Confidence 0.47 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.72 Pain Relevance 0.03

aging (Aqp2) plasma membrane (Aqp2) protein complex (Aqp2) transmembrane transport (Aqp2) lysosome (Aqp2) cytoplasm (Aqp2)

Anatomy Link Frequency urine 2 Aqp2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat medulla 1 56.24 isoflurane 4 5.00 anesthesia 3 5.00 antagonist 3 5.00 fibrosis 1 5.00 bradykinin 1 5.00

Disease Link Frequency Relevance Heat Chronic Renal Failure 124 83.32 Uremia 4 38.28 Congenital Anomalies 1 30.56 Hypertrophy 11 5.00 Natriuresis 2 5.00 Fibrosis 1 5.00 Disorders Of Creatine Metabolism 1 5.00 Bartter Syndrome 1 5.00 Hypercalcemia 1 5.00 Pressure And Volume Under Development 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interestingly, in a parallel study, we found that treatment with the AT1 receptor blocker candesartan in NaCl-restricted normal rats prevented the increase of the expression of inner medullary AQP2 and phosphorylated-AQP2 (AQP2 phosphorylated in the PKA-phosphorylation consensus site Ser-256) and the increase of urine concentration in response to the long-term dDAVP treatment (25).

Positive_regulation (increase) of Positive_regulation (increase) of AQP2 in urine

1) Confidence 0.47 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.72 Pain Relevance 0.03

General Comments

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