INT293358

Context Info Confidence 0.00 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.07 Pain Relevance 0.03

cytoplasm (FKBP1A, CABIN1) isomerase activity (FKBP1A) protein folding (FKBP1A) cytosol (FKBP1A) signal transduction (FKBP1A) nucleolus (CABIN1)

FKBP1A (Homo sapiens) CABIN1 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 19 52.32 corticosteroid 37 24.12 fibrosis 10 21.92 Inflammation 10 5.00 Bioavailability 6 5.00 Paracetamol 3 5.00 Antihistamine 2 5.00 agonist 2 5.00 tolerance 2 5.00 anticonvulsant 1 5.00

Disease Link Frequency Relevance Heat Organ Transplantation 5 71.12 Toxicity 1 41.56 Fibrosis 8 21.92 Hepatitis C Virus Infection 52 5.00 Recurrence 23 5.00 Nephrotoxicity 13 5.00 Renal Failure 11 5.00 INFLAMMATION 10 5.00 Cytomegalovirus Infection 8 5.00 Cirrhosis 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Csa and tacrolimus are calcineurin inhibitors that bind to their specific immunophilins, cyclophilin and FK binding protein, respectively, before the drug-receptor complex binds to and inhibits calcineurin, a calcium-dependent phosphatase.

FK binding protein Binding (bind) of calcineurin

1) Confidence 0.00 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.07 Pain Relevance 0.03

General Comments

This test has worked.