INT294446

Context Info Confidence 0.01 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0.10

peptidase activity (KLK4) extracellular region (KLK4)

Anatomy Link Frequency extracellular matrix 2 KLK4 (Homo sapiens) HAS2 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 10 97.28 anesthesia 12 5.00 fibrosis 12 5.00 Inflammation 12 5.00 Inflammatory response 6 5.00 ischemia 4 5.00 alcohol 4 5.00 chemokine 4 5.00 Bile 2 5.00 tolerance 2 5.00

Disease Link Frequency Relevance Heat Malignant Neoplastic Disease 4 29.76 Cancer 24 27.68 Chronic Hepatitis C 4 22.64 Chronic Hepatitis 18 8.00 Stress 24 5.00 Injury 20 5.00 INFLAMMATION 18 5.00 Cirrhosis 16 5.00 Hepatitis C Virus Infection 12 5.00 Hypoxia 12 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The 23 up-regulated genes mainly encoded proteins involved in immune response (interferon pathway, growth factor, growth factor receptor, cytokine: IL8, CXCR4, CCL2, CXCL1, IL6, CCL3, CCL4, LIF, CXCL5, IL1A); and matrix remodeling (angiogenesis, extracellular matrix, extracellular matrix protease, inhibitors of matrix protease: PAI1, THBS1, PTGS2, HIF1A, MMP9, CTGF, HAS2, PAI2, MMP2, and COL1A1).

matrix protease Negative_regulation (inhibitors) of HAS2 in extracellular matrix associated with cytokine

1) Confidence 0.01 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0 Pain Relevance 0.05

The 23 up-regulated genes mainly encoded proteins involved in immune response (interferon pathway, growth factor, growth factor receptor, cytokine: IL8, CXCR4, CCL2, CXCL1, IL6, CCL3, CCL4, LIF, CXCL5, IL1A); and matrix remodeling (angiogenesis, extracellular matrix, extracellular matrix protease, inhibitors of matrix protease: PAI1, THBS1, PTGS2, HIF1A, MMP9, CTGF, HAS2, PAI2, MMP2, and COL1A1).

matrix protease Negative_regulation (inhibitors) of HAS2 in extracellular matrix associated with cytokine

2) Confidence 0.00 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0 Pain Relevance 0.05

General Comments

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