INT294605

Context Info Confidence 0.13 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 2.68 Pain Relevance 0.09

unfolded protein binding (Serpinh1) endoplasmic reticulum (Serpinh1) protein maturation (Serpinh1) response to stress (Serpinh1) cytoplasm (Serpinh1)

Anatomy Link Frequency lens 3 cornea 1 Serpinh1 (Mus musculus)

Pain Link Frequency Relevance Heat tolerance 8 85.60 anesthesia 6 5.00 Inflammation 6 5.00 ketamine 4 5.00 corticosteroid 2 5.00 alcohol 2 5.00

Disease Link Frequency Relevance Heat Wound Healing 24 100.00 Cataract 40 99.48 Targeted Disruption 28 87.92 Stress 30 79.20 Shock 30 75.00 Injury 18 62.88 Corneal Opacity 10 5.00 Fever 8 5.00 INFLAMMATION 6 5.00 Myopia 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In light of these facts, the increased levels of Hsp 70 and Hsp 47 appeared to be major factors in the protection of the cornea and lens against lethal thermal damage, as well as played an important role in rapid wound healing, and decreased corneal and lens opacity after excimer laser ablation.

Negative_regulation (decreased) of Gene_expression (levels) of Hsp 47 in lens associated with wound healing and cataract

1) Confidence 0.13 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 1.34 Pain Relevance 0.04

In light of these facts, the increased levels of Hsp 70 and Hsp 47 appeared to be major factors in the protection of the cornea and lens against lethal thermal damage, as well as played an important role in rapid wound healing, and decreased corneal and lens opacity after excimer laser ablation.

Negative_regulation (decreased) of in cornea Gene_expression (levels) of Hsp 47 in lens associated with wound healing and cataract

2) Confidence 0.04 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 1.34 Pain Relevance 0.04

General Comments

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