INT294708

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.92
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CRP, VCAM1) aging (VCAM1) extracellular region (CRP)
cell adhesion (VCAM1) plasma membrane (VCAM1)
Anatomy Link Frequency
endothelial cells 2
CRP (Homo sapiens)
VCAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 43 97.44 Very High Very High Very High
Inflammation 47 97.04 Very High Very High Very High
Angina 1 80.96 Quite High
Inflammatory response 2 58.80 Quite High
Etanercept 1 34.92 Quite Low
spinal inflammation 2 27.32 Quite Low
rheumatoid arthritis 1 13.24 Low Low
Kinase C 10 5.00 Very Low Very Low Very Low
bradykinin 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 20 100.00 Very High Very High Very High
INFLAMMATION 49 97.04 Very High Very High Very High
Obesity 8 95.08 Very High Very High Very High
Atherosclerotic Plaque 1 93.64 High High
Apoptosis 89 91.00 High High
Increased Venous Pressure Under Development 25 90.60 High High
Insulin Resistance 27 84.00 Quite High
Cv General 3 Under Development 2 80.96 Quite High
Hyperglycemia 38 76.44 Quite High
Renal Disease 2 65.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In endothelial cells, CRP increased the expression of vascular cell adhesion molecule (VCAM-1) and intracellular adhesion molecule (ICAM-1), and increased MCP-1 production and tissue factor release [8,21].
CRP Positive_regulation (increased) of Gene_expression (expression) of VCAM-1 in endothelial cells associated with adhesions
1) Confidence 0.31 Published 2008 Journal Archives of Drug Information Section Body Doc Link PMC2817441 Disease Relevance 0.76 Pain Relevance 0.32
CRP increases the expression of endothelial ICAM-1, VCAM-1, E-selectin, MCP-1 and increases the secretion of ET1.
CRP Positive_regulation (increases) of Gene_expression (expression) of VCAM-1
2) Confidence 0.05 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.16 Pain Relevance 0.24

General Comments

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