INT294726

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Context Info
Confidence 0.49
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.06
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Lts1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 35 98.16 Very High Very High Very High
Potency 4 91.12 High High
Inflammatory mediators 2 88.60 High High
agonist 3 85.36 High High
Inflammation 33 83.28 Quite High
sodium channel 1 76.24 Quite High
headache 2 73.28 Quite High
Pain 3 72.72 Quite High
Angina 4 71.48 Quite High
cytokine 6 30.44 Quite Low
Disease Link Frequency Relevance Heat
Atherosclerosis 46 99.84 Very High Very High Very High
Cystic Fibrosis 35 98.16 Very High Very High Very High
Acute Coronary Syndrome 18 97.52 Very High Very High Very High
Keratosis 32 97.40 Very High Very High Very High
Stroke 2 96.36 Very High Very High Very High
INFLAMMATION 30 88.20 High High
Respiratory Failure 1 85.44 High High
Pseudomonas Infection 3 82.56 Quite High
Malignant Neoplastic Disease 13 81.80 Quite High
Bacterial Infection 1 81.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Metabolism of non-esterified AA by COX enzymes yields PGs (prostaglandins), while LOX enzymes generate LTs (leukotrienes) and HETEs (hydroxyeicosatetraenoic acids).
Positive_regulation (generate) of LTs
1) Confidence 0.49 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2990202 Disease Relevance 0.06 Pain Relevance 0
Receptors responding to Cys-LTs have been cloned in 1999 and termed CysLT1 and CysLT2 [22].
Positive_regulation (termed) of LTs
2) Confidence 0.07 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2817543 Disease Relevance 0 Pain Relevance 0.13
Taken together, experimental and genetic studies suggest a major role of LTs in atherosclerosis and in its ischemic complications such as acute coronary syndromes and stroke [64].
Positive_regulation (role) of LTs associated with acute coronary syndrome, stroke and atherosclerosis
3) Confidence 0.07 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2817543 Disease Relevance 0.94 Pain Relevance 0.26
Pioneer clinical studies revealed increased levels of prostaglandins (PGs) and leukotrienes (LTs) in broncho-alveolar lavage fluids (BALF) of CF patients [4].
Positive_regulation (increased) of LTs associated with fibrosis
4) Confidence 0.05 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 1.57 Pain Relevance 0.48
However, we believe that LTS is underestimated probably because of the lack of importance assigned to multiple SK (mSK) in personal clinical surveys.
Positive_regulation (underestimated) of LTS associated with keratosis
5) Confidence 0.04 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2820021 Disease Relevance 1.49 Pain Relevance 0

General Comments

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