INT294824

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Context Info
Confidence 0.69
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 7.64
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Sparc) extracellular space (Sparc) extracellular region (Sparc)
proteinaceous extracellular matrix (Sparc) nucleus (Sparc) intracellular (Sparc)
Anatomy Link Frequency
fibroblasts 2
skin 2
Sparc (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory marker 3 98.16 Very High Very High Very High
fibrosis 99 96.92 Very High Very High Very High
Inflammation 36 96.40 Very High Very High Very High
Inflammatory response 3 85.28 High High
corticosteroid 7 82.12 Quite High
dexamethasone 8 81.60 Quite High
ischemia 2 81.28 Quite High
cytokine 2 56.08 Quite High
Potency 4 19.04 Low Low
Spinal cord 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 129 99.92 Very High Very High Very High
Apoptosis 20 99.92 Very High Very High Very High
Breast Cancer 65 99.84 Very High Very High Very High
Acute Coronary Syndrome 106 99.44 Very High Very High Very High
Systemic Sclerosis 30 99.28 Very High Very High Very High
INFLAMMATION 40 98.16 Very High Very High Very High
Myocardial Infarction 10 97.80 Very High Very High Very High
Colon Cancer 2 97.46 Very High Very High Very High
Atherosclerosis 7 97.24 Very High Very High Very High
Fibrosis 159 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Notably, increased expression of SPARC has been observed in affected skin and circulation of patients with SSc [10,11], a devastating disease of systemic fibrosis, as well as in cultured dermal fibroblasts obtained from SSc skin [8,9].
Positive_regulation (increased) of Gene_expression (expression) of SPARC in skin associated with fibrosis, disease and systemic sclerosis
1) Confidence 0.69 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 1.83 Pain Relevance 0.34
While precise mechanism of these changes is still unknown, increased expression of SPARC was reported to correlate with the levels of inflammatory markers [32,33].
Positive_regulation (increased) of Gene_expression (expression) of SPARC associated with inflammatory marker
2) Confidence 0.69 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.66 Pain Relevance 0.30
After transfection of SPARC siRNA, the fibroblasts showed a decreased expression of Col1a2 that was originally over-expressed in the TBR1CA; Cre-ER mice (Figure 2).
Positive_regulation (transfection) of Gene_expression (transfection) of SPARC siRNA in fibroblasts
3) Confidence 0.50 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.33 Pain Relevance 0
Compared with parental MIP101 colorectal cancer cells, calcitriol markedly reduces cell growth and enhances calcitriol alone- or calcitriol+fluorouracil-induced apoptosis in SPARC-overexpressing MIP101 cells 64.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of SPARC associated with colon cancer and apoptosis
4) Confidence 0.49 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 0.76 Pain Relevance 0.04
Recent studies have shown that local production of SPARC is essential for maintenance of the integrity of cardiac ECM after MI, emphasizing the potential therapeutic application of this protein to prevent cardiac dilatation and dysfunction after MI [35].
Positive_regulation (essential) of Gene_expression (production) of SPARC associated with myocardial infarction
5) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954807 Disease Relevance 0.67 Pain Relevance 0.03
As mentioned above, one of the secreted proteins identified in our study was SPARC, which is primarily released from ?
Positive_regulation (mentioned) of Gene_expression (one) of SPARC
6) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954807 Disease Relevance 0.45 Pain Relevance 0.04
SPARC is overexpressed in breast cancer and has been implicated in tumor progression and angiogenesis.31 Nab-paclitaxel enhances tumor targeting through gp60 and caveolae-mediated endothelial transcytosis and the association with the albumin-binding protein SPARC in the tumor microenvironment.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of SPARC associated with cancer and breast cancer
7) Confidence 0.30 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886338 Disease Relevance 1.25 Pain Relevance 0
The HER2-positive tumors had variable SPARC expression.
Positive_regulation (variable) of Gene_expression (expression) of SPARC associated with cancer
8) Confidence 0.22 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886338 Disease Relevance 1.07 Pain Relevance 0
Toom et al. [18] found that the expression of BMP-2 and TGF are higher in ectopic bones and Chauvean et al. [19] reported strong over expression of osteocalcin mRNA, an event associated with upregulation of osteonectin and collagen type I synthesis.
Positive_regulation (upregulation) of Gene_expression (synthesis) of osteonectin
9) Confidence 0.16 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956094 Disease Relevance 0.27 Pain Relevance 0.06
These results are generally consistent with what has been observed in conjunction with the overexpression of adipogenesis- and osteogenesis-related transcription factors, including RXR, osteonectin, AP, and PPAR-gamma, after de-differentiation (Figure 5A).
Positive_regulation (overexpression) of Gene_expression (overexpression) of osteonectin
10) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.35 Pain Relevance 0

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