INT294866

Context Info Confidence 0.04 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.43 Pain Relevance 0

anatomical structure formation involved in morphogenesis (Sox2) DNA binding (Sox2) cytoplasm (Sox2) cytosol (Sox2) nucleus (Sox2) molecular_function (Sox2)

Sox2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Spinal cord 12 5.00 Action potential 4 5.00 Sciatic nerve 3 5.00 Potency 3 5.00 anesthesia 1 5.00 withdrawal 1 5.00

Disease Link Frequency Relevance Heat Hypoxia 35 92.08 Spinal Cord Injury 15 5.00 Diabetes Mellitus 12 5.00 Death 6 5.00 Obesity 6 5.00 Aging 6 5.00 Injury 4 5.00 Apoptosis 4 5.00 Severe Combined Immunodeficiency 3 5.00 Stress 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

, MEK, MEKK, and raf proteins during cell proliferation, and also induced a profound reduction in ERK1/2 and p38 activation and CDKs, Rex-1, and Sox-2 downregulation following treatment with specific inhibitors.

Negative_regulation (downregulation) of Sox-2

1) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.43 Pain Relevance 0

General Comments

This test has worked.