INT294924

Context Info Confidence 0.39 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.07 Pain Relevance 0

signal transduction (IGF1) extracellular space (IGF1) extracellular region (IGF1)

Anatomy Link Frequency pituitary 3 thyroid 2 hypothalamus 1 IGF1 (Homo sapiens)

Pain Link Frequency Relevance Heat dexamethasone 2 7.12 Bioavailability 5 5.00 iatrogenic 4 5.00 Somatostatin 3 5.00 fibrosis 2 5.00 Pain 2 5.00 agonist 2 5.00 Potency 2 5.00 imagery 2 5.00 Clonidine 1 5.00

Disease Link Frequency Relevance Heat Thyroid Disease 28 98.72 Adrenal Cancer 182 88.72 Cretinism 1 86.44 Congenital Anomalies 3 80.60 Hypothyroidism 2 78.12 Thyroiditis 1 60.84 Osteoporosis 2 46.80 Apoptosis 2 39.28 Hypertension 54 25.64 Weight Gain 14 25.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As a matter of fact, a direct effect of thyroid function on IGF-I secretion was not fully confirmed in our study, as there were no significant differences in an increase of IGF-I secretion between the euthyroid children and those, who presented with hypothyroidism during rhGH administration.

Regulation (effect) of Localization (secretion) of IGF-I in thyroid associated with thyroid disease

1) Confidence 0.39 Published 2010 Journal Thyroid Res Section Body Doc Link PMC2858102 Disease Relevance 0.79 Pain Relevance 0

Glucocorticoids interfere with the normal interactions in the growth hormone (GH)/IGF-1 signaling cascade at the level of the hypothalamus, pituitary, and target organ as well as adversely affect hormone release, signal and gene transduction, and mRNA processing [36].

Regulation (affect) of Localization (cascade) of IGF-1 in pituitary

2) Confidence 0.09 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2817857 Disease Relevance 0.14 Pain Relevance 0

Glucocorticoids interfere with the normal interactions in the growth hormone (GH)/IGF-1 signaling cascade at the level of the hypothalamus, pituitary, and target organ as well as adversely affect hormone release, signal and gene transduction, and mRNA processing [36].

Regulation (affect) of in hypothalamus Localization (cascade) of IGF-1 in pituitary

3) Confidence 0.03 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2817857 Disease Relevance 0.14 Pain Relevance 0

General Comments

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