INT29519

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Context Info
Confidence 0.66
First Reported 1988
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.99
Pain Relevance 4.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Ednrb) signal transduction (Ednrb) plasma membrane (Ednrb)
signal transducer activity (Ednrb)
Anatomy Link Frequency
spinal 1
sciatic nerves 1
neurons 1
Brain 1
Ednrb (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 33 100.00 Very High Very High Very High
antinociception 1 99.96 Very High Very High Very High
Pain 3 99.82 Very High Very High Very High
Nav1.6 2 99.60 Very High Very High Very High
substantia gelatinosa 57 99.56 Very High Very High Very High
Nav1.7 2 99.16 Very High Very High Very High
Sciatic nerve 2 99.00 Very High Very High Very High
Inflammation 18 98.96 Very High Very High Very High
dorsal root ganglion 12 98.52 Very High Very High Very High
unmyelinated 3 98.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 8 100.00 Very High Very High Very High
Nociception 11 99.00 Very High Very High Very High
INFLAMMATION 30 98.96 Very High Very High Very High
Ganglion Cysts 12 98.52 Very High Very High Very High
Repression 1 84.32 Quite High
Pressure And Volume Under Development 2 60.64 Quite High
Inflammatory Pain 3 45.92 Quite Low
Overactive Bladder 16 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Targeted disruption of the endothelin-B-receptor gene attenuates inflammatory nociception and cutaneous inflammation in mice.
Gene_expression (disruption) of endothelin-B associated with nociception, pain and inflammation
1) Confidence 0.66 Published 2000 Journal J. Cardiovasc. Pharmacol. Section Title Doc Link 11078342 Disease Relevance 1.00 Pain Relevance 0.40
Gpr109b/PUMA-G, Fpr1, Ccrl2 and Ednrb) ([12-16], Sweet et al, unpublished data), regulated expression of others has not been widely studied.
Gene_expression (expression) of Ednrb
2) Confidence 0.58 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.08 Pain Relevance 0
These results show that delta-selective receptor antagonists produced antinociception which was related to the mu-receptor, but was probably not a result of direct agonist action.
Gene_expression (produced) of delta-selective receptor associated with antinociception, antagonist and agonist
3) Confidence 0.35 Published 1988 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2834753 Disease Relevance 0 Pain Relevance 0.84
Consistent with these results, we have demonstrated a reduction in Nav1.8 and Nav1.9 immunostaining on peripherin-positive unmyelinated axons in sciatic nerves from CNTN-/- mice but detected no changes in the expression for the two major TTX-S channels Nav1.6 and Nav1.7.
Gene_expression (expression) of TTX-S in sciatic nerves associated with sciatic nerve, nav1.8, nav1.7, nav1.6, unmyelinated and nav1.9
4) Confidence 0.03 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16029194 Disease Relevance 0.37 Pain Relevance 1.31
These data provide evidence of a role for contactin in selectively regulating the cell surface expression and current densities of TTX-R but not TTX-S Na+ channel isoforms in nociceptive DRG neurons; this regulation could modulate the membrane properties and excitability of these neurons.
Gene_expression (expression) of TTX-S in neurons associated with nociception and dorsal root ganglion
5) Confidence 0.03 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16029194 Disease Relevance 0.53 Pain Relevance 1.23
Using line scanning confocal microscopy it has been reported that electrically-evoked NCTs can be detected 6 ms after stimulation (Brain et al., 2002), suggesting that the real delay between the sEJP and NCT is much briefer than the range of values, ?
Gene_expression (sEJP) of sEJP in Brain
6) Confidence 0.01 Published 2007 Journal Neuroscience Section Body Doc Link PMC2543106 Disease Relevance 0 Pain Relevance 0.16
The relationship between sDeps and sAPs
Gene_expression (sDeps) of sDeps
7) Confidence 0.01 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2655397 Disease Relevance 0 Pain Relevance 0.03
Furthermore, GluR5 antagonist LY293558 inhibited both sIPSC and mIPSC frequencies in spinal SG neurons.
Gene_expression (frequencies) of sIPSC in spinal associated with substantia gelatinosa and antagonist
8) Confidence 0.00 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.58

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