INT295384

Context Info Confidence 0.14 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

protein transporter activity (Xpo1) nucleoplasm (Xpo1) nucleolus (Xpo1) RNA binding (Xpo1) nucleus (Xpo1) cytoplasm (Xpo1)

Anatomy Link Frequency P19 1 Xpo1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat dorsal root ganglion 14 5.00 opioid receptor 4 5.00 Dynorphin 3 5.00 Pain 2 5.00

Disease Link Frequency Relevance Heat Ganglion Cysts 14 5.00 Pain 2 5.00 Targeted Disruption 1 5.00 Death 1 5.00 Adhesions 1 5.00 Cognitive Disorder 1 5.00 Stress 1 5.00 Diuresis 1 5.00 Cytomegalovirus Infection 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To validate SHP-2 as the activated phosphatase in response to EGF stimulation, the effect of SHP-2 on Grb7 phosphorylation and complex formation of Grb7, HuR, and CRM1 was examined by siRNA knockdown of SHP-2 in P19 cells.

Phosphorylation (phosphorylation) of CRM1 in P19

1) Confidence 0.14 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0 Pain Relevance 0

General Comments

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