INT295415

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.44
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Bmi1) nucleus (Bmi1)
Bmi1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 47 96.44 Very High Very High Very High
antidepressant 16 89.88 High High
sSRI 4 89.08 High High
tolerance 1 21.28 Low Low
sNRI 4 5.00 Very Low Very Low Very Low
Serotonin 3 5.00 Very Low Very Low Very Low
monoamine 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
fluoxetine 1 5.00 Very Low Very Low Very Low
Duloxetine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 12 100.00 Very High Very High Very High
Depression 62 96.44 Very High Very High Very High
Diabetes Mellitus 47 87.92 High High
Overweight 2 85.00 Quite High
Weight Loss 1 83.52 Quite High
Disorder Of Lipid Metabolism 3 60.80 Quite High
Body Weight 1 59.84 Quite High
Disease 1 35.44 Quite Low
Death 1 5.00 Very Low Very Low Very Low
Chronic Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, another study of a compound with a marked noradrenergic component, bupropion, found that BMI and HbA1c levels decreased significantly during the acute treatment phase with an association between reduction of depression severity and reduction of HbA1c levels.30 Clearly, further studies are required to investigate the possible importance of the noradrenergic component of antidepressant action on metabolic parameters in diabetes.


Negative_regulation (decreased) of BMI associated with antidepressant, depression, diabetes mellitus and obesity
1) Confidence 0.42 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2819761 Disease Relevance 1.44 Pain Relevance 0.27

General Comments

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