INT295837

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Context Info
Confidence 0.49
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.55
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Srpk1) chromosome segregation (Srpk1) mRNA processing (Srpk1)
nucleus (Srpk1) kinase activity (Srpk1) cytoplasm (Srpk1)
Anatomy Link Frequency
proximal 1
nucleus 1
Srpk1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 4 64.24 Quite High
anesthesia 4 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Myeloid Leukemia 4 87.04 High High
Leukemia 4 83.16 Quite High
Apoptosis 4 69.52 Quite High
Cancer 28 64.72 Quite High
Hypoxia 8 41.84 Quite Low
Retinal Neovascularization 12 40.24 Quite Low
Lung Cancer 4 33.64 Quite Low
Targeted Disruption 4 32.28 Quite Low
Sarcoma 4 30.56 Quite Low
Skin Cancer 8 22.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SRPK1 has been shown to phosphorylate ASF/SF2, which we have previously shown to favor proximal splice site selection.
Phosphorylation (phosphorylate) of SRPK1 in proximal
1) Confidence 0.49 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0
It thus appears likely that SRPK1-mediated phosphorylation of ASF/SF2 could support an activation of the PSS and increased production of pro-angiogenic isoforms.
Phosphorylation (phosphorylation) of SRPK1
2) Confidence 0.49 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0.13 Pain Relevance 0
SRPK1 has been shown specifically to phosphorylate 12 serines of the RS domain in ASF/SF2 (31), and SRPK2 has been involved in the localization of ASF/SF2 within the nucleus.
Phosphorylation (phosphorylate) of SRPK1 in nucleus
3) Confidence 0.49 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0.03
Moreover, SRPK1 and SRPK2 are known to phosphorylate the ASF/SF2 splicing factor with high specificity (21, 31, 53).
Phosphorylation (phosphorylate) of SRPK1
4) Confidence 0.49 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0.42 Pain Relevance 0

General Comments

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