INT295924

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Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.82
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Accn2)
Accn2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ASIC 330 100.00 Very High Very High Very High
ischemia 232 100.00 Very High Very High Very High
tolerance 28 81.92 Quite High
addiction 6 71.12 Quite High
imagery 18 66.72 Quite High
GABAergic 6 50.88 Quite High
Pyramidal cell 22 42.96 Quite Low
Immobilon 4 36.88 Quite Low
PcTx1 4 30.96 Quite Low
Glutamate 10 23.64 Low Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 220 100.00 Very High Very High Very High
Injury 20 96.88 Very High Very High Very High
Apoptosis 20 89.92 High High
Death 36 89.36 High High
Stroke 12 77.28 Quite High
Acidosis 46 72.32 Quite High
Brain Hemorrhage 14 50.00 Quite Low
Necrosis 8 5.00 Very Low Very Low Very Low
Epilepsy 8 5.00 Very Low Very Low Very Low
Convulsion 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specificity of the ASIC1a antibody was checked by Western blotting showing that the antibody only detected ?
Regulation (checked) of Gene_expression (antibody) of ASIC1a
1) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937019 Disease Relevance 0 Pain Relevance 0
Pharmacologically, ASIC currents in NG2 cells were sensitive to amiloride (100 µM), a blocker for the degenerin/epithelial Na+ channel (DEG/ENaC) superfamily (control, 183±34 pA; amiloride, 33±4 pA, n?
Regulation (sensitive) of Gene_expression (currents) of ASIC associated with asic
2) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937019 Disease Relevance 0 Pain Relevance 0.53
Further studies showed that global ischemia up-regulated the expression of ASIC 2a, a finding that is in accordance with a previous study [27].
Regulation (regulated) of Gene_expression (expression) of ASIC associated with ischemia and asic
3) Confidence 0.12 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.92 Pain Relevance 0.53
Our study showed that global ischemia up-regulated the expression of ASIC 2a in the hippocampal CA1 region.
Regulation (regulated) of Gene_expression (expression) of ASIC associated with ischemia and asic
4) Confidence 0.12 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.71 Pain Relevance 0.63
Western blot was used to assess the effect of global ischemia and ischemic preconditioning on ASIC 2a protein expression (Figure 4).
Regulation (effect) of Gene_expression (expression) of ASIC associated with ischemia and asic
5) Confidence 0.12 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.65 Pain Relevance 0.66
Further studies showed that global ischemia up-regulated the expression of ASIC 2a.
Regulation (regulated) of Gene_expression (expression) of ASIC associated with ischemia and asic
6) Confidence 0.05 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.54 Pain Relevance 0.26

General Comments

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