INT296280

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.45
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Car2, Dlg4) cytosol (Car2) extracellular space (Car2)
lyase activity (Car2) structural molecule activity (Dlg4) plasma membrane (Dlg4)
Car2 (Mus musculus)
Dlg4 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 159 100.00 Very High Very High Very High
depression 93 80.08 Quite High
Dynorphin 6 79.64 Quite High
Hippocampus 36 76.72 Quite High
opiate 3 76.40 Quite High
long-term potentiation 60 56.08 Quite High
Lasting pain 6 50.12 Quite High
antagonist 15 50.00 Quite Low
Glutamate receptor 6 12.60 Low Low
tail-flick 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 93 80.08 Quite High
Anxiety Disorder 72 79.44 Quite High
Pain 9 50.12 Quite High
Targeted Disruption 63 40.00 Quite Low
Repression 3 35.96 Quite Low
Shock 27 5.00 Very Low Very Low Very Low
Nociception 9 5.00 Very Low Very Low Very Low
Brain Disease 3 5.00 Very Low Very Low Very Low
Drug Dependence 3 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, Ca2+-insensitive TgDREAM may constitutively interact with PSD-95 and inhibit NMDA receptor trafficking or there is an impaired recruitment of TgDREAM-bound PSD-95 to synaptic protein complexes needed for NMDA receptor function.
Ca2 Binding (interact) of PSD-95 associated with nmda receptor
1) Confidence 0.19 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.19 Pain Relevance 0.66
Therefore, Ca2+-insensitive TgDREAM may constitutively interact with PSD-95 and inhibit NMDA receptor trafficking or there is an impaired recruitment of TgDREAM-bound PSD-95 to synaptic protein complexes needed for NMDA receptor function.
Ca2 Binding (bound) of PSD-95 associated with nmda receptor
2) Confidence 0.15 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.26 Pain Relevance 0.70
Furthermore, the role of Ca2+ in the interaction between DREAM and PSD-95 was studied.
Ca2 Binding (interaction) of PSD-95
3) Confidence 0.14 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0 Pain Relevance 0.36

General Comments

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