INT296285

Context Info Confidence 0.14 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.32 Pain Relevance 0.72

transport (Grin2b) lyase activity (Car1) Golgi apparatus (Car1) plasma membrane (Grin2b) embryo development (Grin2b) cytoplasm (Car1)

Anatomy Link Frequency neurons 1 Car1 (Mus musculus) Grin2b (Mus musculus)

Pain Link Frequency Relevance Heat nMDA receptor 53 99.60 antagonist 5 86.56 Glutamate receptor 2 79.24 depression 31 74.04 Pyramidal cell 3 70.68 long-term potentiation 20 68.64 Hippocampus 12 10.96 tail-flick 3 5.00 Lasting pain 2 5.00 Central nervous system 2 5.00

Disease Link Frequency Relevance Heat Depression 31 74.04 Anxiety Disorder 24 50.00 Targeted Disruption 21 47.16 Repression 1 5.12 Shock 9 5.00 Pain 3 5.00 Nociception 3 5.00 Brain Disease 1 5.00 Drug Dependence 1 5.00 Urological Neuroanatomy 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Functional NMDA receptors in the hippocampal CA1 neurons contain mainly heterogenic combinations of the NR1 with NR2A or NR2B subunits [46].

CA1 Binding (combinations) of NR2B in neurons associated with nmda receptor

1) Confidence 0.14 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.32 Pain Relevance 0.72

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