INT296307

Context Info Confidence 0.11 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 5 Disease Relevance 7.10 Pain Relevance 1.15

nucleus (SPIN1) cell cycle (SPIN1)

SPIN1 (Homo sapiens)

Pain Link Frequency Relevance Heat endometriosis 275 99.84 Dismenorea 10 5.00 pain pelvic 5 5.00 fibrosis 5 5.00 Inflammation 5 5.00

Disease Link Frequency Relevance Heat Ovarian Cancer 445 100.00 Endometriosis 280 99.84 Gynecological Disease 5 93.92 Cancer 20 91.40 Disease 45 5.00 Dysmenorrhea 10 5.00 Fibrosis 5 5.00 Adhesions 5 5.00 Pathologic Processes 5 5.00 Reprotox - General 3 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The first interesting results in our study were the constant increase of the number ovarian cancer since 1997 to 2006.

Positive_regulation (increase) of ovarian cancer associated with ovarian cancer

1) Confidence 0.11 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2822768 Disease Relevance 1.68 Pain Relevance 0.18

We showed a constant increase in the number of ovarian cancer (OC) between 1997 and 2006 (r2 = 0.557, P = 0.013), which is not the case for endometriosis (ENDO) or endometriosis-associated ovarian cancer (EAOC).

Positive_regulation (increase) of ovarian cancer associated with endometriosis and ovarian cancer

2) Confidence 0.08 Published 2010 Journal J Ovarian Res Section Abstract Doc Link PMC2822768 Disease Relevance 2.17 Pain Relevance 0.50

Endometriosis has been believed to increase the risk of developing ovarian cancer, but recent data supporting this hypothesis are lacking.

Positive_regulation (increase) of ovarian cancer associated with endometriosis and ovarian cancer

3) Confidence 0.08 Published 2010 Journal J Ovarian Res Section Abstract Doc Link PMC2822768 Disease Relevance 0.68 Pain Relevance 0.17

The second findings of our study showed that the cohort of endometriosis women had an increased risk of ovarian cancer of 1.6 (95% CI 1.12-2.09).

Positive_regulation (increased) of ovarian cancer associated with endometriosis and ovarian cancer

4) Confidence 0.08 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2822768 Disease Relevance 1.25 Pain Relevance 0.14

These data are consistent with other studies highlighting the increased risk of ovarian cancer in endometriosis patients [6,7,18].

Positive_regulation (increased) of ovarian cancer associated with endometriosis and ovarian cancer

5) Confidence 0.08 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2822768 Disease Relevance 1.32 Pain Relevance 0.17

General Comments

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