INT296446

Context Info Confidence 0.13 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.55 Pain Relevance 0.57

transport (Gria2, Gria4) plasma membrane (Gria2, Gria4) endoplasmic reticulum (Gria2) protein complex (Gria2)

Anatomy Link Frequency spinal 1 Gria2 (Mus musculus) Gria4 (Mus musculus)

Pain Link Frequency Relevance Heat Kinase C 36 98.80 Central nervous system 16 98.56 Spinal cord 20 79.84 agonist 2 77.76 Dorsal horn neuron 12 66.56 Glutamate receptor 22 58.76 spinal dorsal horn 14 54.16 Inflammation 18 48.56 Dorsal horn 12 47.92 Glutamate 4 20.88

Disease Link Frequency Relevance Heat Nociception 52 99.00 Hypersensitivity 4 73.48 INFLAMMATION 18 48.56 Depression 4 17.16 Pain 16 15.12 Neuropathic Pain 8 9.88 Inflammatory Pain 18 8.88 Hyperalgesia 10 5.00 Injury 4 5.00 Nervous System Injury 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Recently, Polgar et al. reported that postsynaptic GluR4-containing AMPA receptors were involved in spinal nociceptive transmission [48].

AMPA Binding (receptors) of GluR4 in spinal associated with nociception

1) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.50 Pain Relevance 0.26

AMPA receptors are heteromeric molecules comprising various combinations of GluR1, GluR2, GluR3, and GluR4 subunits.

AMPA Binding (combinations) of GluR4

2) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.05 Pain Relevance 0.32

General Comments

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