INT296453

Context Info Confidence 0.02 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.23 Pain Relevance 0.31

plasma membrane (Gria1, Mpdz) cytosol (Gria1) transport (Gria1) cell adhesion (Mpdz) endoplasmic reticulum (Gria1) protein complex (Gria1)

Anatomy Link Frequency synapse 3 Gria1 (Mus musculus) Mpdz (Mus musculus)

Pain Link Frequency Relevance Heat IPN 27 76.80 Spinal sensitization 3 56.88 central sensitization 27 49.80 nMDA receptor 12 43.44 Neuropathic pain 12 17.52 Kinase C 54 13.12 Spinal cord 30 7.76 Glutamate receptor 33 5.00 Pain 30 5.00 Inflammation 27 5.00

Disease Link Frequency Relevance Heat Inflammatory Pain 27 76.80 Hyperalgesia 15 19.60 Neuropathic Pain 12 17.52 Nociception 78 5.00 INFLAMMATION 27 5.00 Pain 24 5.00 Depression 6 5.00 Injury 6 5.00 Nervous System Injury 6 5.00 Hypersensitivity 6 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Another PDZ domain protein, synapse-associated protein 97 (SAP 97) binds to the C-terminus of GluR1 subunit and interacts with the actin-associated protein 4.1N (which can also bind GluR1 subunit).

GluR1 Binding (binds) of PDZ domain protein in synapse

1) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.08 Pain Relevance 0.10

Another PDZ domain protein, synapse-associated protein 97 (SAP 97) binds to the C-terminus of GluR1 subunit and interacts with the actin-associated protein 4.1N (which can also bind GluR1 subunit).

GluR1 Binding (interacts) of PDZ domain protein in synapse

2) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.08 Pain Relevance 0.11

Another PDZ domain protein, synapse-associated protein 97 (SAP 97) binds to the C-terminus of GluR1 subunit and interacts with the actin-associated protein 4.1N (which can also bind GluR1 subunit).

GluR1 Binding (binds) of PDZ domain protein in synapse

3) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.08 Pain Relevance 0.10

General Comments

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