INT296477

Context Info Confidence 0.04 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.22 Pain Relevance 0.42

transport (Cacng2) structural molecule activity (Dlg4) plasma membrane (Dlg4) protein complex assembly (Dlg4) neurological system process (Cacng2) cytoplasm (Dlg4)

Anatomy Link Frequency spinal 1 tail 1 Cacng2 (Mus musculus) Dlg4 (Mus musculus)

Pain Link Frequency Relevance Heat Spinal sensitization 2 98.76 nMDA receptor 8 97.56 central sensitization 18 97.36 Kinase C 36 77.44 Hyperalgesia 8 54.40 Inflammation 18 53.88 spinal dorsal horn 14 46.76 IPN 18 28.96 Neuropathic pain 8 15.28 Glutamate receptor 22 5.00

Disease Link Frequency Relevance Heat Nociception 52 59.04 Hyperalgesia 10 54.40 INFLAMMATION 18 53.88 Inflammatory Pain 18 28.96 Neuropathic Pain 8 15.28 Pain 16 5.00 Depression 4 5.00 Injury 4 5.00 Nervous System Injury 4 5.00 Hypersensitivity 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus, it may suggest that the Stargazin-mediated interaction of AMPA receptors with PSD-95 is possibly implicated in the spinal sensitization.

Stargazin Binding (interaction) of PSD-95 in spinal associated with spinal sensitization

1) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0 Pain Relevance 0.17

Binding of the C-terminal tail of Stargazin to PDZ domains of a number of synaptic scaffolding proteins, such as PSD-95 (an interacting protein associated with NR2 subunits of the NMDA receptors) may mediate the synaptic targeting of surface AMPA receptors [56].

Stargazin Binding (Binding) of PSD-95 in tail associated with nmda receptor

2) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.22 Pain Relevance 0.24

General Comments

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