INT296615

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.51
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Smad2) DNA binding (Smad2) protein complex (Smad2)
transcription factor binding (Smad2) cytoplasm (Smad2)
Anatomy Link Frequency
proximal 2
Smad2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 27 5.00 Very Low Very Low Very Low
fibrosis 18 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ureteral Obstruction 75 99.72 Very High Very High Very High
Fibrosis 60 90.16 High High
Stress 36 78.08 Quite High
Injury 18 65.52 Quite High
INFLAMMATION 24 5.00 Very Low Very Low Very Low
Pulmonary Fibrosis 9 5.00 Very Low Very Low Very Low
Apoptosis 9 5.00 Very Low Very Low Very Low
Renal Disease 9 5.00 Very Low Very Low Very Low
Hypersensitivity 9 5.00 Very Low Very Low Very Low
Renal Failure 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-SMA and activated smad2 (p-smad2) levels in proximal tubular epithelial cells.
Positive_regulation (activated) of smad2 in proximal
1) Confidence 0.50 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2823698 Disease Relevance 0.50 Pain Relevance 0
These studies demonstrated that nuclear p-smad2 was significantly increased after UUO and that juglone prevented nuclear p-smad2 activity.
Positive_regulation (increased) of p-smad2 associated with ureteral obstruction
2) Confidence 0.43 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2823698 Disease Relevance 0.50 Pain Relevance 0
-SMA and activated smad2 (p-smad2) levels in proximal tubular epithelial cells.
Positive_regulation (activated) of p-smad2 in proximal
3) Confidence 0.29 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2823698 Disease Relevance 0.51 Pain Relevance 0

General Comments

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