INT29678

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Context Info
Confidence 0.42
First Reported 1988
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.06
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cga) molecular_function (Cga) cellular_component (Cga)
biological_process (Cga)
Anatomy Link Frequency
pituitary 4
posterior pituitary 2
neural 2
Cga (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 2 100.00 Very High Very High Very High
narcan 3 99.66 Very High Very High Very High
Neuropeptide 6 99.40 Very High Very High Very High
antagonist 2 99.16 Very High Very High Very High
Serotonin 1 97.36 Very High Very High Very High
Opioid 4 96.04 Very High Very High Very High
MU agonist 1 91.00 High High
Dynorphin 6 90.40 High High
Endogenous opioid 3 89.80 High High
fluoxetine 3 82.08 Quite High
Disease Link Frequency Relevance Heat
Opiate Addiction 1 56.04 Quite High
Aids-related Complex 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulus-induced depletion of pro-enkephalins, oxytocin and vasopressin and pro-enkephalin interaction with posterior pituitary hormone release in vitro.
Negative_regulation (depletion) of Localization (release) of pituitary hormone in posterior pituitary associated with narcan and enkephalin
1) Confidence 0.42 Published 1994 Journal Neuroendocrinology Section Title Doc Link 7700499 Disease Relevance 0.06 Pain Relevance 1.00
While it has been shown that intracerebral administration of exogenous glucocorticoids diminishes pituitary luteinizing hormone (LH) release, it is not known if these hormones act directly on gonadotropin-releasing hormone (GnRH)-synthesizing neurons, or if their central inhibitory effects are mediated by specific neural substrates.
Negative_regulation (diminishes) of Localization (release) of pituitary luteinizing hormone in neural
2) Confidence 0.10 Published 1995 Journal Neuropeptides Section Abstract Doc Link 7791961 Disease Relevance 0 Pain Relevance 0.26
Several hypothalamic neuropeptides and amino acids are known to inhibit or excite pituitary luteinizing hormone (LH) release, but the precise interplay between these 2 classes of signals in episodic LH discharge is not known.
Negative_regulation (inhibit) of Localization (release) of pituitary luteinizing hormone in pituitary associated with neuropeptide
3) Confidence 0.07 Published 1994 Journal J. Neuroendocrinol. Section Abstract Doc Link 7827626 Disease Relevance 0 Pain Relevance 0.52
The serotonin (5-hydroxytryptamine, 5-HT) precursor 5-hydroxy-L-tryptophan (5-HTP) and 5-HT antagonists, respectively, are able to stimulate and block pituitary adrenocorticotropin (ACTH) release.
Negative_regulation (block) of Localization (release) of pituitary adrenocorticotropin in pituitary associated with antagonist and serotonin
4) Confidence 0.04 Published 1988 Journal Neuroendocrinology Section Abstract Doc Link 2840594 Disease Relevance 0 Pain Relevance 0.23

General Comments

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