INT296793

Context Info Confidence 0.11 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.75 Pain Relevance 0.65

nucleus (Akt1, Bax) cytoplasm (Akt1, Bax) cytosol (Akt1, Bax) mitochondrion (Bax) transport (Akt1) aging (Akt1)

Akt1 (Mus musculus) Bax (Mus musculus)

Pain Link Frequency Relevance Heat Morphine 60 98.16 agonist 1 91.52 Inflammation 8 22.48 cytokine 7 5.28 Opioid 18 5.00 Inflammatory response 2 5.00 drug abuse 1 5.00 anesthesia 1 5.00 opiate 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Infection 31 99.56 Targeted Disruption 20 87.96 Apoptosis 37 87.20 Mycobacterial Infection 44 50.00 INFLAMMATION 10 22.48 Drug Dependence 4 5.00 Sprains And Strains 3 5.00 Cancer 2 5.00 Increased Venous Pressure Under Development 2 5.00 Pain 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Activated Akt induces the alteration of Bcl2 and Bax expression and plays an antiapoptotic role in several different cell types [26].

Akt Positive_regulation (induces) of Gene_expression (expression) of Bax

1) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824811 Disease Relevance 0.75 Pain Relevance 0.65

General Comments

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