INT296845

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 4.76
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (B4galnt2) Golgi apparatus (B4galnt2)
Anatomy Link Frequency
neuronal 1
brains 1
B4galnt2 (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 24 97.48 Very High Very High Very High
Hippocampus 20 5.00 Very Low Very Low Very Low
Limbic system 12 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Locus ceruleus 4 5.00 Very Low Very Low Very Low
Neurobehavioral 4 5.00 Very Low Very Low Very Low
Substantia nigra 4 5.00 Very Low Very Low Very Low
Immobilon 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 236 100.00 Very High Very High Very High
Disease 220 99.96 Very High Very High Very High
Lysosome Storage Disease 8 98.28 Very High Very High Very High
Gauchers Disease 12 96.84 Very High Very High Very High
Pick Disease Of The Brain 12 95.28 Very High Very High Very High
Targeted Disruption 40 89.68 High High
Neurodegenerative Disease 36 86.08 High High
Dementia 36 82.48 Quite High
Movement Disorders 8 81.44 Quite High
Aging 8 79.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further supporting a role for lysosomal dysfunction in DLB and PD, recent studies have shown that in lysosomal storage disorders such as Gaucher disease [43], [44] and Niemann-Pick disease [45], there is increased predisposition to develop parkinsonism and ?
Regulation (role) of DLB associated with parkinson's disease, pick disease of the brain, gauchers disease, disease and lysosome storage disease
1) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 1.32 Pain Relevance 0
Levels of other components of the autophagy pathway such as Atg5, Atg10, Atg12 and Beclin-1 were not different in DLB compared to controls.
Regulation (different) of DLB associated with parkinson's disease
2) Confidence 0.05 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2824828 Disease Relevance 1.52 Pain Relevance 0
However it was unclear which molecular components of the autophagy pathway might be dysregulated in the brains of patients with DLB/PD and in ?
Regulation (dysregulated) of DLB in brains associated with parkinson's disease and disease
3) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 1.01 Pain Relevance 0
In contrast, in DLB cases levels of neuronal mTor immunoreactivity were increased (Figure 2C, G), while the levels of neuronal Atg7 immunolabeling were reduced (Figure 2F, G).
Regulation (immunoreactivity) of DLB in neuronal associated with parkinson's disease
4) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.91 Pain Relevance 0.08

General Comments

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