INT296851

Context Info Confidence 0.60 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.82 Pain Relevance 0.14

transport (Atg7) neurological system process (Atg7) cellular amino acid metabolic process (Atg7) cytoplasm (Atg7)

Anatomy Link Frequency dendrites 1 Atg7 (Mus musculus)

Pain Link Frequency Relevance Heat Hippocampus 10 96.88 Pyramidal cell 12 96.12 Limbic system 6 5.00 anesthesia 2 5.00 Locus ceruleus 2 5.00 Neurobehavioral 2 5.00 Substantia nigra 2 5.00 Immobilon 2 5.00 imagery 2 5.00

Disease Link Frequency Relevance Heat Parkinson's Disease 118 99.16 Neurodegenerative Disease 18 82.48 Disease 110 76.44 Targeted Disruption 20 72.68 Dementia 18 71.08 Neurological Disease 2 62.84 Lewy Body Disease 12 50.00 Pick Disease Of The Brain 6 40.64 Gauchers Disease 6 39.64 Lysosome Storage Disease 4 17.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Atg7 immunostaining was localized primarily to the neuronal perykaria surrounding the injection track with some extension to the apical dendrites (Figure 9E).

Localization (localized) of Atg7 in dendrites

1) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.30 Pain Relevance 0.14

In conclusion, this study supports the notion that selective molecular alterations in the autophagy pathway and more specifically in mTor and Atg7 are associated with DLB and ?

Localization (alterations) of Atg7 associated with parkinson's disease

2) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.53 Pain Relevance 0

General Comments

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