INT296856

Context Info Confidence 0.05 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 2.08 Pain Relevance 0.09

cytosol (Mtor) mitochondrion (Mtor) Golgi apparatus (Mtor) endoplasmic reticulum (Mtor) nucleus (Mtor) kinase activity (Mtor)

Anatomy Link Frequency neurons 2 brains 2 Mtor (Mus musculus)

Pain Link Frequency Relevance Heat Pyramidal cell 12 90.12 Hippocampus 10 5.00 Limbic system 6 5.00 anesthesia 2 5.00 Locus ceruleus 2 5.00 Neurobehavioral 2 5.00 Substantia nigra 2 5.00 Immobilon 2 5.00 imagery 2 5.00

Disease Link Frequency Relevance Heat Parkinson's Disease 118 98.48 Aging 4 94.36 Movement Disorders 4 93.84 Neurodegenerative Disease 18 93.68 Dementia 18 92.92 Disease 110 90.84 Lewy Body Disease 12 80.32 Infection 10 22.76 Targeted Disruption 20 5.00 Gauchers Disease 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The increased levels of mTor and reduced Atg7 levels suggest there may be altered activation of the autophagy pathway in the brains of DLB patients.

Negative_regulation (reduced) of Gene_expression (levels) of mTor in brains associated with parkinson's disease

1) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.90 Pain Relevance 0.09

-syn tg mice levels of mTor were elevated and Atg7 expression was reduced. mTor and LC3 was co-localized with neurons displaying ?

Negative_regulation (reduced) of Gene_expression (expression) of mTor in neurons

2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 1.18 Pain Relevance 0

General Comments

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