INT296901

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Context Info
Confidence 0.29
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.29
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neck 2
osteoclasts 2
Tmie (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Morphine 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 34 99.80 Very High Very High Very High
Osteoporotic Fractures 8 96.88 Very High Very High Very High
Hypoxia 52 82.28 Quite High
Stress 6 79.44 Quite High
Apoptosis 25 77.36 Quite High
Postmenopausal Osteoporosis 10 69.88 Quite High
Shock 1 65.84 Quite High
Death 6 59.12 Quite High
Hypercalcemia 14 56.96 Quite High
Endometriosis (extended) 2 54.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In TROPOS, at three years in the SR group a 5.7% baseline percentage increment in BMD was observed at the femoral neck and 7.1% at the total hip (P = 0.001), compared with the placebo group.22
Positive_regulation (increment) of Gene_expression (group) of SR in neck
1) Confidence 0.29 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971725 Disease Relevance 0.24 Pain Relevance 0
SR is composed of two atoms of stable strontium and one molecule of ranelic acid.4 SR is a treatment for osteoporosis and unlike other drugs, has a dual effect on bone remodeling, being able to stimulate bone formation by osteoblasts, a property shared with bone-forming agents, and to inhibit bone resumption by osteoclasts, as antiresumptive agents.5,6
Positive_regulation (treatment) of Gene_expression (composed) of SR in osteoclasts associated with osteoporosis
2) Confidence 0.29 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971725 Disease Relevance 0.48 Pain Relevance 0
Several studies have shown that expression of SR genes was increased by antioxidants and ?
Positive_regulation (increased) of Gene_expression (expression) of SR
3) Confidence 0.01 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.57 Pain Relevance 0

General Comments

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