INT297237

Context Info Confidence 0.16 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.13 Pain Relevance 0

peptidase activity (Ncstn) Golgi apparatus (Ncstn) endoplasmic reticulum (Ncstn) plasma membrane (Ncstn)

Anatomy Link Frequency Notch 2 Ncstn (Mus musculus)

Pain Link Frequency Relevance Heat Central nervous system 1 8.36 Thalamus 27 5.00 Hippocampus 6 5.00 Pyramidal cell 2 5.00 anesthesia 1 5.00 Neurotransmitter 1 5.00

Disease Link Frequency Relevance Heat Scrapie 23 73.76 Creutzfeldt Jakob Disease 36 51.84 Disease 23 12.72 Stress Incontinence 35 5.00 Death 7 5.00 Sprains And Strains 5 5.00 Toxicity 3 5.00 Kuru 2 5.00 Infection 2 5.00 Sleep Disorders 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This suggests that between 60 and 100 days truncated Notch-1 was being formed at a faster rate than Nicastrin could transport it to ?

Positive_regulation (rate) of Transcription (transport) of Nicastrin in Notch

1) Confidence 0.16 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2825502 Disease Relevance 0.13 Pain Relevance 0

General Comments

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