INT297343

Context Info Confidence 0.09 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.94 Pain Relevance 0.14

cytoplasm (Apoe, Tlr4) transport (Apoe) aging (Apoe) Golgi apparatus (Apoe) intracellular (Tlr4) lipid metabolic process (Apoe)

Apoe (Mus musculus) Tlr4 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammatory response 1 99.32 Inflammation 12 89.36 cytokine 13 88.32 Neuritis 24 10.64 Peripheral nervous system 5 5.00 Multiple sclerosis 5 5.00 chemokine 1 5.00 Demyelination 1 5.00 Sciatic nerve 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 13 99.32 Targeted Disruption 19 95.44 Hyperlipidemia 2 94.28 Cancer 1 87.12 Necrosis 1 86.64 Anaerobic Bacterial Infections 1 72.12 Immunization 2 71.60 Hypersensitivity 1 69.08 Endotoxemia 1 59.84 Mycobacterial Infection 1 51.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

ApoE can bind lipopolysaccharide (LPS), attenuate the inflammatory response, and thus reduce LPS induced lethality [53].

ApoE Binding (bind) of LPS associated with inflammatory response

1) Confidence 0.09 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.94 Pain Relevance 0.14

General Comments

This test has worked.