INT297351

Context Info Confidence 0.41 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.81 Pain Relevance 0.33

nucleus (EWSR1, PPARA) nucleoplasm (PPARA) small molecule metabolic process (PPARA) intracellular (EWSR1) DNA binding (PPARA) lipid metabolic process (PPARA)

EWSR1 (Homo sapiens) PPARA (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 2 96.80 agonist 33 94.72 cINOD 7 61.76 Inflammation 7 12.24 Inflammatory response 5 5.00 methotrexate 1 5.00 withdrawal 1 5.00 headache 1 5.00

Disease Link Frequency Relevance Heat Chondrosarcoma 2 100.00 Fibrosarcoma 1 97.92 Cancer 46 97.60 Breast Cancer 7 94.32 Apoptosis 20 93.48 Reprotox - General 1 3 81.40 Lung Cancer 1 77.88 Stomach Cancer 2 76.76 Intestinal Cancer 1 76.48 Leukemia 2 76.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The fusion protein EWSRI/NR4A3 in extraskeletal chondrosarcomas activates PPAR?

EWS Positive_regulation (activates) of PPAR associated with chondrosarcoma

1) Confidence 0.41 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 1.81 Pain Relevance 0.33

General Comments

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