INT297358

Context Info Confidence 0.75 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 2.64 Pain Relevance 0.35

Anatomy Mention Frequency macrophages 1 fibroblasts 1

Pain Term Frequency Confidence Heat cINOD 7 90.72 agonist 33 83.16 methotrexate 1 5.00 withdrawal 1 5.00 Angina 2 5.00 Inflammation 7 5.00 Inflammatory response 7 5.00 headache 1 5.00 antagonist 2 5.00

Disease Term Frequency Confidence Heat Osteogenic Sarcomas 79 93.08 Apoptosis 26 92.96 Disorder Of Lipid Metabolism 14 89.12 Osteoporosis 17 85.20 Disease 10 84.40 Death 4 67.36 Atherosclerosis 24 66.32 Coronary Artery Disease 84 57.56 Bladder Cancer 1 55.48 Atherosclerotic Plaque 4 55.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Loss of NPC1 function leads to defective suppression of sterol regulatory element binding protein (SREBP)-dependent gene expression and failure to appropriately activate liver X receptor-mediated pathways, ultimately resulting in intracellular cholesterol accumulation in macrophages and fibroblasts[7,8].

Gene_expression (expression) of SREBP in macrophages

1) Confidence 0.75 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2966454 Disease Relevance 0.66 Pain Relevance 0

-induced expression of C/EBP and ADD1/SREBP, suggesting that the drug resistance may occur through the inhibition of PPAR?

Gene_expression (expression) of SREBP

2) Confidence 0.58 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 1.32 Pain Relevance 0.35

Loss of NPC1 function leads to defective suppression of sterol regulatory element binding protein (SREBP)-dependent gene expression and failure to appropriately activate liver X receptor-mediated pathways, ultimately resulting in intracellular cholesterol accumulation in macrophages and fibroblasts[7,8].

Gene_expression (expression) of SREBP in fibroblasts

3) Confidence 0.26 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2966454 Disease Relevance 0.66 Pain Relevance 0

General Comments

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