INT297531

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Context Info
Confidence 0.32
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 5.49
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ece1) peptidase activity (Ece1) Golgi apparatus (Ece1)
plasma membrane (Ece1)
Anatomy Link Frequency
placenta 2
ventricle 1
Ece1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 45 99.16 Very High Very High Very High
fibrosis 20 98.48 Very High Very High Very High
Calcium channel 2 96.36 Very High Very High Very High
metalloproteinase 66 84.80 Quite High
Pain 5 84.56 Quite High
antagonist 29 80.32 Quite High
Dismenorea 3 57.52 Quite High
headache 1 28.72 Quite Low
Kinase C 3 27.76 Quite Low
Central nervous system 3 20.44 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 55 99.16 Very High Very High Very High
Fibrosis 21 98.48 Very High Very High Very High
Premature Birth 120 98.40 Very High Very High Very High
Infection 131 96.56 Very High Very High Very High
Pre-term Labor 39 95.72 Very High Very High Very High
Sprains And Strains 14 94.68 High High
Cardiomyopathy 25 93.40 High High
Urinary Tract Infection 23 89.96 High High
Respiratory Disease 1 88.44 High High
Adult Respiratory Distress Syndrome 88 86.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To our knowledge, it is the first clinical trial to investigate the preventive efficacy of ECE for 6 months after the end of treatment.
Spec (investigate) Negative_regulation (preventive) of ECE
1) Confidence 0.32 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2826739 Disease Relevance 0.84 Pain Relevance 0.08
Furthermore, those mice in which ECE-1 and, consequently, MMP-1 levels were reduced were largely prevented from developing preterm delivery (manuscript submitted).
Negative_regulation (reduced) of ECE-1 associated with premature birth
2) Confidence 0.31 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.77 Pain Relevance 0.17
We reported in 2004 that inhibition of endothelin-converting enzyme-1 (ECE-1), which colocalizes with ET-1 in the placenta [66], controls PTD in a mouse model of infection-associated PTL [67].
Negative_regulation (inhibition) of ECE-1 in placenta associated with pre-term labor and infection
3) Confidence 0.31 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.66 Pain Relevance 0.13
We reported in 2004 that inhibition of endothelin-converting enzyme-1 (ECE-1), which colocalizes with ET-1 in the placenta [66], controls PTD in a mouse model of infection-associated PTL [67].
Negative_regulation (inhibition) of endothelin-converting enzyme-1 in placenta associated with pre-term labor and infection
4) Confidence 0.31 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.66 Pain Relevance 0.13
Among the metalloproteases, angiotensin-converting enzyme [28], endothelin-converting enzyme [29] and insulin-degrading enzymes [30] are only slightly inhibited by thiorphan.
Negative_regulation (inhibited) of endothelin-converting enzyme
5) Confidence 0.16 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 1.11 Pain Relevance 0.07
Phosphoramidon, a potent inhibitor of endothelin-converting enzyme, reduced myocardium inflammation and fibrosis and attenuated right ventricle diameter increase in CD1 mice infected with the Brazil strain of T. cruzi and treated for the initial 15 days post-infection [125].


Negative_regulation (inhibitor) of endothelin-converting enzyme in ventricle associated with fibrosis, inflammation, sprains and strains and infection
6) Confidence 0.08 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930857 Disease Relevance 1.46 Pain Relevance 0.29

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