INT297619

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.40
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (RLN3)
RLN3 (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 2 5.00 Very Low Very Low Very Low
pruritus 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 5 95.24 Very High Very High Very High
Leukemia 10 93.88 High High
Ovarian Cancer 13 85.92 High High
Cancer 47 84.72 Quite High
Fatigue 18 84.60 Quite High
Vomiting 29 84.08 Quite High
Multiple Myeloma 2 80.88 Quite High
Non-small-cell Lung Cancer 8 79.44 Quite High
Reprotox - General 1 5 76.56 Quite High
Solid Tumor 12 69.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LBH589, a novel hydroxamate analog HDAC inhibitor, has been shown to induce acetylation of histone H3 and H4, increase p21 levels, disrupt the chaperone function of hsp90, and induce cell-cycle G1 phase accumulation and apoptosis of K562 cells and acute leukemia MV4-11 cells [102].
H3 Binding (acetylation) of associated with leukemia and apoptosis
1) Confidence 0.02 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2827364 Disease Relevance 1.40 Pain Relevance 0

General Comments

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