INT298257

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.54 Pain Relevance 0.03

peptidase activity (Proc) extracellular space (Proc) extracellular region (Proc) nucleus (Pou4f1) DNA binding (Pou4f1)

Pou4f1 (Mus musculus) Proc (Mus musculus)

Pain Link Frequency Relevance Heat trigeminal ganglion 75 57.88 nociceptor 32 20.64 calcitonin gene related peptide 11 5.00 Neuropeptide 4 5.00 mu opioid receptor 4 5.00 substance P 3 5.00 Somatostatin 3 5.00 Central nervous system 2 5.00 Spinal cord 2 5.00 Serotonin 2 5.00

Disease Link Frequency Relevance Heat Neurodegenerative Disease 3 100.00 Targeted Disruption 43 92.92 Herpes Simplex Virus 1 76.40 Repression 7 71.44 Ganglion Cysts 85 57.88 Pain 3 5.00 Nociception 3 5.00 Death 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, direct regulation has been demonstrated only for bHLH transcription factors that are expressed early in sensory neurogenesis and subsequently repressed by Brn3a [14], and a direct transcriptional activator function has not been demonstrated for Brn3a in vivo.

Brn3a Negative_regulation (repressed) of factors associated with neurodegenerative disease

1) Confidence 0.01 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.54 Pain Relevance 0.03

General Comments

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