INT298261

Context Info Confidence 0.45 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.58 Pain Relevance 0.40

nucleus (Pou4f1, Runx1) DNA binding (Pou4f1, Runx1) transcription factor binding (Runx1)

Pou4f1 (Mus musculus) Runx1 (Mus musculus)

Pain Link Frequency Relevance Heat Neuropeptide 4 98.04 trigeminal ganglion 75 97.76 nociceptor 32 96.00 Central nervous system 2 47.96 calcitonin gene related peptide 11 5.00 mu opioid receptor 4 5.00 substance P 3 5.00 Somatostatin 3 5.00 Spinal cord 2 5.00 Serotonin 2 5.00

Disease Link Frequency Relevance Heat Ganglion Cysts 85 97.76 Targeted Disruption 43 83.60 Repression 7 67.00 Neurodegenerative Disease 3 35.32 Pain 3 5.00 Nociception 3 5.00 Death 2 5.00 Herpes Simplex Virus 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

During embryogenesis, Brn3a is required to initiate normal expression of the fate selector genes Runx3 and Runx1.

Brn3a Negative_regulation (initiate) of Gene_expression (expression) of Runx1

1) Confidence 0.45 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.58 Pain Relevance 0.40

General Comments

This test has worked.