INT298278

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Context Info
Confidence 0.44
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.80
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk2) cytosol (Ntrk2) plasma membrane (Ntrk2)
nucleus (Runx1) DNA binding (Runx1) kinase activity (Ntrk2)
Runx1 (Mus musculus)
Ntrk2 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 150 82.28 Quite High
nociceptor 64 78.00 Quite High
Neuropeptide 8 75.52 Quite High
Central nervous system 4 25.44 Quite Low
calcitonin gene related peptide 22 5.00 Very Low Very Low Very Low
mu opioid receptor 8 5.00 Very Low Very Low Very Low
substance P 6 5.00 Very Low Very Low Very Low
Somatostatin 6 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Serotonin 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 86 85.04 High High
Ganglion Cysts 170 82.28 Quite High
Repression 14 48.52 Quite Low
Neurodegenerative Disease 6 12.80 Low Low
Pain 6 5.00 Very Low Very Low Very Low
Nociception 6 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together these data show that Brn3a creates a permissive condition for the expression of the Runx factors, which then repress TrkB expression and allow differentiation of the principal sensory subtypes.


Runx Negative_regulation (repress) of Gene_expression (expression) of TrkB
1) Confidence 0.44 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.39 Pain Relevance 0.28
Together these data show that Brn3a acts upstream of the Runx factors, which then repress TrkB expression to allow establishment of the non-overlapping Trk receptor profiles and correct terminally differentiated phenotypes.



Runx Negative_regulation (repress) of Gene_expression (expression) of TrkB
2) Confidence 0.44 Published 2010 Journal Neural Dev Section Abstract Doc Link PMC2829025 Disease Relevance 0.40 Pain Relevance 0.27

General Comments

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