INT298283

Context Info Confidence 0.50 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 1.40 Pain Relevance 1.48

nucleus (Pou4f1, Runx1) DNA binding (Pou4f1, Runx1) transcription factor binding (Runx1)

Anatomy Link Frequency nociceptor 4 sensory neurons 2 Pou4f1 (Mus musculus) Runx1 (Mus musculus)

Pain Link Frequency Relevance Heat trigeminal ganglion 225 100.00 nociceptor 96 99.96 substance P 9 92.96 calcitonin gene related peptide 33 91.92 Somatostatin 9 88.48 Pain 6 82.80 opioid receptor 3 76.40 tetrodotoxin-resistant sodium channels 3 66.32 nav1.8 3 62.64 Nav1.9 3 61.20

Disease Link Frequency Relevance Heat Ganglion Cysts 255 100.00 Repression 21 91.68 Pain 9 82.80 Targeted Disruption 129 74.56 Nociception 9 5.00 Neurodegenerative Disease 9 5.00 Death 6 5.00 Herpes Simplex Virus 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Brn3a is required for Runx1 expression and the segregation of TrkA/TrkB expression in nociceptor precursors

Brn3a Positive_regulation (required) of Gene_expression (expression) of Runx1 in nociceptor associated with nociceptor

1) Confidence 0.50 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.35 Pain Relevance 0.24

Brn3a is required for the expression of a battery of Runx1-dependent nociceptor markers

Brn3a Positive_regulation (required) of Gene_expression (expression) of Runx1-dependent in nociceptor associated with nociceptor

2) Confidence 0.50 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.48 Pain Relevance 0.94

Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation The transcription factor Brn3a, product of the pou4f1 gene, is expressed in most sensory neurons throughout embryogenesis.

Brn3a Positive_regulation (promoting) of Gene_expression (expression) of Runx in sensory neurons associated with ganglion cysts and trigeminal ganglion

3) Confidence 0.43 Published 2010 Journal Neural Dev Section Title Doc Link PMC2829025 Disease Relevance 0.56 Pain Relevance 0.30

General Comments

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