INT298346

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Context Info
Confidence 0.53
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 1.17
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HES3) DNA binding (HES3) transcription factor binding (HES3)
Anatomy Link Frequency
brain 2
stem cells 2
Precursor cells 1
HES3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 7 97.00 Very High Very High Very High
Central nervous system 63 95.52 Very High Very High Very High
midbrain 28 89.08 High High
Dopamine 35 85.68 High High
cerebral cortex 7 55.20 Quite High
Substantia nigra 14 5.00 Very Low Very Low Very Low
Perioperative pain 7 5.00 Very Low Very Low Very Low
Hippocampus 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 70 99.42 Very High Very High Very High
Stroke 21 5.00 Very Low Very Low Very Low
Neurological Disease 14 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low
Injury 7 5.00 Very Low Very Low Very Low
Post Operative Pain 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Precursor cells in human tumor and non-cancerous tissue co-express Hes3 (Figure 2A–C).
Gene_expression (express) of Hes3 in Precursor cells associated with cancer
1) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829079 Disease Relevance 0.36 Pain Relevance 0.08
Here, in addition to previously defined self-renewal markers, we used Hes3 expression to assess fast changes in cell state and to determine if Hes3 also recognizes cancer stem cells arising in the CNS.
Gene_expression (expression) of Hes3 in stem cells associated with cancer and central nervous system
2) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829079 Disease Relevance 0.26 Pain Relevance 0.05
NSCs from the adult rodent and monkey brain express Hes3; differentiation causes a rapid loss of Hes3 expression [6].
Gene_expression (express) of Hes3 in brain
3) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829079 Disease Relevance 0 Pain Relevance 0.06
All proliferating cells expressed the NSC markers nestin [38], Sox2 [39], and Hes3 [6] (Figure 1G–H).
Gene_expression (expressed) of Hes3
4) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829079 Disease Relevance 0 Pain Relevance 0.12
These treatments support the self renewal state of cultured NSCs and expression of the transcription factor Hes3, which also identifies the cancer stem cell population in human tumors.
Gene_expression (expression) of Hes3 in stem cell associated with cancer
5) Confidence 0.53 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2829079 Disease Relevance 0.20 Pain Relevance 0.15
Fetal mouse NSCs prospectively isolated by prominin expression are six fold enriched for Hes3 expression (6.42±1.9, n?
Gene_expression (expression) of Hes3
6) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829079 Disease Relevance 0.36 Pain Relevance 0.11
NSCs from the adult rodent and monkey brain express Hes3; differentiation causes a rapid loss of Hes3 expression [6].
Gene_expression (expression) of Hes3 in brain
7) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829079 Disease Relevance 0 Pain Relevance 0.06

General Comments

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