INT298346

Context Info Confidence 0.53 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 7 Disease Relevance 1.17 Pain Relevance 0.63

nucleus (HES3) DNA binding (HES3) transcription factor binding (HES3)

Anatomy Link Frequency brain 2 stem cells 2 Precursor cells 1 HES3 (Homo sapiens)

Pain Link Frequency Relevance Heat Spinal cord 7 97.00 Central nervous system 63 95.52 midbrain 28 89.08 Dopamine 35 85.68 cerebral cortex 7 55.20 Substantia nigra 14 5.00 Perioperative pain 7 5.00 Hippocampus 7 5.00

Disease Link Frequency Relevance Heat Cancer 70 99.42 Stroke 21 5.00 Neurological Disease 14 5.00 Disease 7 5.00 Injury 7 5.00 Post Operative Pain 7 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Precursor cells in human tumor and non-cancerous tissue co-express Hes3 (Figure 2A–C).

Gene_expression (express) of Hes3 in Precursor cells associated with cancer

1) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829079 Disease Relevance 0.36 Pain Relevance 0.08

Here, in addition to previously defined self-renewal markers, we used Hes3 expression to assess fast changes in cell state and to determine if Hes3 also recognizes cancer stem cells arising in the CNS.

Gene_expression (expression) of Hes3 in stem cells associated with cancer and central nervous system

2) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829079 Disease Relevance 0.26 Pain Relevance 0.05

NSCs from the adult rodent and monkey brain express Hes3; differentiation causes a rapid loss of Hes3 expression [6].

Gene_expression (express) of Hes3 in brain

3) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829079 Disease Relevance 0 Pain Relevance 0.06

All proliferating cells expressed the NSC markers nestin [38], Sox2 [39], and Hes3 [6] (Figure 1G–H).

Gene_expression (expressed) of Hes3

4) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829079 Disease Relevance 0 Pain Relevance 0.12

These treatments support the self renewal state of cultured NSCs and expression of the transcription factor Hes3, which also identifies the cancer stem cell population in human tumors.

Gene_expression (expression) of Hes3 in stem cell associated with cancer

5) Confidence 0.53 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2829079 Disease Relevance 0.20 Pain Relevance 0.15

Fetal mouse NSCs prospectively isolated by prominin expression are six fold enriched for Hes3 expression (6.42±1.9, n?

Gene_expression (expression) of Hes3

6) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829079 Disease Relevance 0.36 Pain Relevance 0.11

NSCs from the adult rodent and monkey brain express Hes3; differentiation causes a rapid loss of Hes3 expression [6].

Gene_expression (expression) of Hes3 in brain

7) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829079 Disease Relevance 0 Pain Relevance 0.06

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