INT29844

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Context Info
Confidence 0.42
First Reported 1988
Last Reported 2002
Negated 1
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.77
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Lpo) cellular_component (Lpo) biological_process (Lpo)
Anatomy Link Frequency
liver 1
kidney 1
Lpo (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 20 100.00 Very High Very High Very High
Paracetamol 7 99.80 Very High Very High Very High
Glutamate 1 57.92 Quite High
Nicotine 1 48.40 Quite Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 1 99.32 Very High Very High Very High
Hepatotoxicity 2 93.04 High High
Nephrotoxicity 4 91.92 High High
Body Weight 2 85.04 High High
Disease 5 60.00 Quite High
Stress 14 33.44 Quite Low
Genetic Predisposition To Disease 1 24.72 Low Low
Nicotine Addiction 5 9.80 Low Low
Cancer 2 7.16 Low Low
Exsanguination 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It showed similar effects on LPO and GSH levels and other antioxidant enzymes studied as were seen after 4 weeks of treatment. 8 weeks of supplementation of AT and CS inhalation showed similar trends as seen after 4 and 6 weeks of treatment (Table 4).
Regulation (effects) of LPO
1) Confidence 0.42 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.06 Pain Relevance 0
In this study we examined the influence of age and gender on MENK-induced LPO levels in the liver and TSA content in splenocytes of CBA mice.
Spec (examined) Regulation (influence) of LPO in liver associated with enkephalin
2) Confidence 0.39 Published 2002 Journal Exp. Gerontol. Section Abstract Doc Link 12559410 Disease Relevance 0.09 Pain Relevance 0.62
Contrary to the effect on LPO level, TSA level in MENK-treated mice was suppressed in both sexes but only in young 2.5-month-old mice.
Regulation (effect) of LPO associated with enkephalin
3) Confidence 0.23 Published 2002 Journal Exp. Gerontol. Section Abstract Doc Link 12559410 Disease Relevance 0.08 Pain Relevance 0.81
These results indicate that LPO is not mainly responsible for paracetamol toxicity towards liver or kidney.
Neg (not) Regulation (responsible) of LPO in kidney associated with toxicity and paracetamol
4) Confidence 0.23 Published 1988 Journal J Appl Toxicol Section Abstract Doc Link 2846674 Disease Relevance 0.54 Pain Relevance 0.52

General Comments

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