INT298465

Context Info Confidence 0.09 First Reported 2010 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.90 Pain Relevance 2.15

endoplasmic reticulum (Gimap1)

Anatomy Link Frequency neuronal 2 skin 2 Gimap1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat inferior alveolar nerve 302 100.00 Neuronal excitability 8 100.00 Action potential 44 99.44 Central nervous system 8 94.96 tetrodotoxin 116 92.20 trigeminal ganglion 132 89.12 hyperexcitability 16 88.88 anesthesia 4 62.88 halothane 4 60.40 Sciatic nerve 2 56.36

Disease Link Frequency Relevance Heat Hypersensitivity 4 97.42 Nociception 2 95.96 Ganglion Cysts 138 89.12 Nervous System Injury 34 49.96 Pain 20 48.60 Neuropathic Pain 16 5.00 Injury 12 5.00 Congenital Anomalies 4 5.00 Camurati-engelmann Disease 2 5.00 Headache 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We used IAN-transected rats which showed hypersensitivity to mechanical stimulation of the mental skin and IAN-transected rats without behavior changes which did not show any behavioral changes after IAN transection for single fiber recording experiments.

Neg (not) Regulation (changes) of Gene_expression (transection) of IAN in skin associated with inferior alveolar nerve and hypersensitivity

1) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829527 Disease Relevance 0.10 Pain Relevance 0.65

In order to evaluate the changes in neuronal excitability associated with the demonstrated changes in sodium and potassium currents following IAN transection, we analyzed action potentials properties under current-clamp conditions.

Regulation (changes) of Gene_expression (transection) of IAN in neuronal associated with action potential, inferior alveolar nerve and neuronal excitability

2) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829527 Disease Relevance 0.80 Pain Relevance 1.50

General Comments

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