INT298758

Context Info Confidence 0.57 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.12 Pain Relevance 0

mitochondrion (ATP5A1) small molecule metabolic process (ATP5A1) transmembrane transporter activity (ATP5A1) ATPase activity (ATP5A1) plasma membrane (ATP5A1) embryo development (ATP5A1)

Anatomy Link Frequency tectal lobes 1 ATP5A1 (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 6 5.00 halothane 2 5.00 peripheral neuropathy 2 5.00 antiepileptic Drug 1 5.00 backache 1 5.00 lidocaine 1 5.00 addiction 1 5.00 agonist 1 5.00 Glutamate 1 5.00 positron emission tomography 1 5.00

Disease Link Frequency Relevance Heat Syndrome 3 59.04 Mitochondrial Disorders 1 58.68 Parkinson's Disease 4 49.68 Muscle Disease 23 48.72 Disease 31 5.00 Coronary Heart Disease 17 5.00 Glycogen Storage Disease 10 5.00 Hypoglycemia 10 5.00 Muscle Weakness 10 5.00 Myoglobinuria 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Using this technique, we have shown that secondary downregulation of ATPsynthase (complex V) occurs in response to reduced electron flow across complexes I–IV [145].

Negative_regulation (downregulation) of ATPsynthase

1) Confidence 0.57 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2877206 Disease Relevance 0.12 Pain Relevance 0

But little is known about the neuronal substrate of the OMR and obtained results were discussed controversially: Springer et al. [14] showed that the OMR of goldfish depends upon an intact tectum opticum: after an ablation of both tectal lobes the OMR of goldfish was completely abolished.

Negative_regulation (abolished) of OMR in tectal lobes

2) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2830482 Disease Relevance 0 Pain Relevance 0

General Comments

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