INT298885

Context Info Confidence 0.31 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.02 Pain Relevance 0

plasma membrane (LAMP2) lysosome (LAMP2)

Anatomy Link Frequency nucleus 1 LAMP2 (Homo sapiens)

Pain Link Frequency Relevance Heat imagery 10 5.44 Pain 6 5.00 Congenital analgesia 2 5.00 Demyelination 2 5.00 Nerve growth factor 2 5.00 Peripheral nervous system 2 5.00

Disease Link Frequency Relevance Heat Disease 152 99.34 Charcot Marie Tooth Disease 12 5.00 Neurodegenerative Disease 8 5.00 Pain 8 5.00 Neurological Disease 4 5.00 Syndrome 4 5.00 Mouth Disease 4 5.00 Ulcers 2 5.00 Demyelinating Disease 2 5.00 Muscle Weakness 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Surprisingly, despite evidence of unregulated activation, Rab7 disease mutants have normal subcellular localization and associate normally with LAMP2 (Fig. 5B) and LysoTracker Red (data not shown).

Localization (localization) of LAMP2 associated with disease

1) Confidence 0.31 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.56 Pain Relevance 0

In contrast, the constitutively active Q67L mutant Rab7 colocalizes with LAMP2, but leads to prominent accumulation of enlarged vesicles that cluster adjacent to the nucleus (Fig. 5A, middle).

Localization (colocalizes) of LAMP2 in nucleus

2) Confidence 0.31 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.46 Pain Relevance 0

General Comments

This test has worked.