INT298901

Context Info Confidence 0.05 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.51 Pain Relevance 0

signal transduction (CLTCL1) mitosis (CLTCL1) vesicle-mediated transport (CLTCL1) structural molecule activity (CLTCL1) signal transducer activity (CLTCL1)

CLTCL1 (Homo sapiens)

Pain Link Frequency Relevance Heat imagery 5 5.00 Pain 3 5.00 Congenital analgesia 1 5.00 Demyelination 1 5.00 Nerve growth factor 1 5.00 Peripheral nervous system 1 5.00

Disease Link Frequency Relevance Heat Disease 76 99.68 Charcot Marie Tooth Disease 6 5.00 Neurodegenerative Disease 4 5.00 Pain 4 5.00 Neurological Disease 2 5.00 Syndrome 2 5.00 Mouth Disease 2 5.00 Ulcers 1 5.00 Demyelinating Disease 1 5.00 Muscle Weakness 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Specifically, Rab7 disease mutants L129F and V162M and the constitutively active mutant Q67L showed increased interaction with Vps13C and ORP1L, whereas only the disease mutants showed increased interaction with clathrin heavy chain, and all constructs interacted equally with REP-1 (Fig. 4C).

Positive_regulation (increased) of clathrin heavy chain Binding (interaction) of associated with disease

1) Confidence 0.05 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.51 Pain Relevance 0

General Comments

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