INT299429

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Context Info
Confidence 0.48
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 13
Disease Relevance 1.55
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Foxl2) nucleus (Foxl2) DNA binding (Foxl2)
transcription factor binding (Foxl2)
Anatomy Link Frequency
granulosa cell 10
Foxl2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 13 5.00 Very Low Very Low Very Low
Dopamine 13 5.00 Very Low Very Low Very Low
adenocard 13 5.00 Very Low Very Low Very Low
Inflammation 13 5.00 Very Low Very Low Very Low
Pain 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 169 93.96 High High
Herpes Simplex Virus 26 91.04 High High
Rheumatoid Arthritis 13 77.40 Quite High
Targeted Disruption 91 64.32 Quite High
Adhesions 26 60.96 Quite High
Syndrome 78 5.00 Very Low Very Low Very Low
Premature Ovarian Failure 65 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 26 5.00 Very Low Very Low Very Low
Blepharophimosis 26 5.00 Very Low Very Low Very Low
Apoptosis 26 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Levels of gene expression were compared between mock transfected cells and those that were transfected with Foxl2-VP16 and Foxl2-MAD, respectively.
Positive_regulation (transfected) of Gene_expression (transfected) of Foxl2
1) Confidence 0.48 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.25 Pain Relevance 0
Levels of gene expression were compared between mock transfected cells and those that were transfected with Foxl2-VP16 and Foxl2-MAD, respectively.
Positive_regulation (transfected) of Gene_expression (transfected) of Foxl2-VP16
2) Confidence 0.48 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.25 Pain Relevance 0
The co-transfection of Foxl2-Mad attenuated the ability of Foxl2-VP16 to activate luciferase expression by 95% (data not shown).
Positive_regulation (transfection) of Gene_expression (transfection) of Foxl2
3) Confidence 0.48 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.24 Pain Relevance 0
Microarray analysis of Foxl2 mediated gene regulation in the mouse ovary derived KK1 granulosa cell line: Over-expression of Foxl2 leads to activation of the gonadotropin releasing hormone receptor gene promoter

Background

Positive_regulation (expression) of Gene_expression (expression) of Foxl2 in granulosa cell
4) Confidence 0.44 Published 2010 Journal J Ovarian Res Section Title Doc Link PMC2831895 Disease Relevance 0 Pain Relevance 0
The effect of Foxl2 over-expression on the activity of the GnRHR promoter was determined by comparing the luciferase activity of the promoter in the presence of pFoxl2 (over-expression) to the activity of the promoter in the absence of Foxl2 over-expression (pcDNA 3.1).
Positive_regulation (over) of Gene_expression (expression) of Foxl2
5) Confidence 0.44 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.06 Pain Relevance 0
One group used the human KGN granulosa cell line and over-expression of FoxL2 to identify potential targets and qPCR to confirm numerous FoxL2 regulated genes [6].
Positive_regulation (over) of Gene_expression (expression) of FoxL2 in granulosa cell
6) Confidence 0.44 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.14 Pain Relevance 0
One group used the human KGN granulosa cell line and over-expression of FoxL2 to identify potential targets and qPCR to confirm numerous FoxL2 regulated genes [6].
Positive_regulation (expression) of Gene_expression (expression) of FoxL2 in granulosa cell
7) Confidence 0.44 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.14 Pain Relevance 0
One group used the human KGN granulosa cell line and over-expression of FoxL2 to identify potential targets and qPCR to confirm numerous FoxL2 regulated genes [6].
Positive_regulation (over) of Gene_expression (over) of FoxL2 in granulosa cell
8) Confidence 0.44 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.14 Pain Relevance 0
The effect of Foxl2 over-expression on the activity of the GnRHR promoter was determined by comparing the luciferase activity of the promoter in the presence of pFoxl2 (over-expression) to the activity of the promoter in the absence of Foxl2 over-expression (pcDNA 3.1).
Positive_regulation (over) of Gene_expression (over) of Foxl2
9) Confidence 0.44 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.06 Pain Relevance 0
One group used the human KGN granulosa cell line and over-expression of FoxL2 to identify potential targets and qPCR to confirm numerous FoxL2 regulated genes [6].
Positive_regulation (expression) of Gene_expression (over) of FoxL2 in granulosa cell
10) Confidence 0.44 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.14 Pain Relevance 0
The effect of Foxl2 over-expression on the activity of the GnRHR promoter was determined by comparing the luciferase activity of the promoter in the presence of pFoxl2 (over-expression) to the activity of the promoter in the absence of Foxl2 over-expression (pcDNA 3.1).
Positive_regulation (expression) of Gene_expression (over) of Foxl2
11) Confidence 0.44 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.06 Pain Relevance 0
The effect of Foxl2 over-expression on the activity of the GnRHR promoter was determined by comparing the luciferase activity of the promoter in the presence of pFoxl2 (over-expression) to the activity of the promoter in the absence of Foxl2 over-expression (pcDNA 3.1).
Positive_regulation (expression) of Gene_expression (expression) of Foxl2
12) Confidence 0.44 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.06 Pain Relevance 0
The results of these analyses indicate that over-expression of Foxl2 resulted in a significant increase in GnRHR promoter activity.
Positive_regulation (over) of Gene_expression (expression) of Foxl2
13) Confidence 0.44 Published 2010 Journal J Ovarian Res Section Abstract Doc Link PMC2831895 Disease Relevance 0 Pain Relevance 0

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