INT299763

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Context Info
Confidence 0.11
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.31
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (APC, Ido1) cytosol (APC, Ido1) plasma membrane (APC, CTLA4)
Golgi apparatus (CTLA4) protein complex assembly (APC) oxidoreductase activity (Ido1)
Anatomy Link Frequency
T cells 2
APC (Homo sapiens)
CTLA4 (Homo sapiens)
Ido1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 4 95.08 Very High Very High Very High
psoriasis 2 64.28 Quite High
rheumatoid arthritis 32 59.36 Quite High
Inflammation 8 52.32 Quite High
abatacept 10 48.64 Quite Low
methotrexate 2 39.52 Quite Low
Arthritis 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 1 76.24 Quite High
Psoriasis 2 64.28 Quite High
Opportunistic Infections 1 62.20 Quite High
Rheumatoid Arthritis 32 59.36 Quite High
INFLAMMATION 9 52.32 Quite High
Disease 17 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Experimental Arthritis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was recently suggested that ligation of CTLA4–Ig with CD80/86 on the APC leads to activation of the enzyme IDO (indoleamine-2,3-oxygenase); this enzyme has the potential to modulate the function of the APC similar to that which has been proposed to occur after interaction of APCs with regulatory CD25+CD4+ T cells [55,56].
APC Binding (ligation) of CTLA4 in T cells Positive_regulation (activation) of IDO
1) Confidence 0.11 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833979 Disease Relevance 0.31 Pain Relevance 0.14

General Comments

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