INT299781

Context Info Confidence 0.01 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.43 Pain Relevance 0.11

extracellular space (Il2) extracellular region (Il2)

Anatomy Link Frequency T cell 2 Cd80 (Mus musculus) Il2 (Mus musculus)

Pain Link Frequency Relevance Heat rheumatoid arthritis 26 93.56 abatacept 40 50.00 Inflammation 1 36.64 cytokine 2 26.76 tolerance 2 21.60 methotrexate 7 5.00 Arthritis 7 5.00 Etanercept 3 5.00 antagonist 3 5.00 corticosteroid 2 5.00

Disease Link Frequency Relevance Heat Apoptosis 2 98.88 Rheumatoid Arthritis 26 93.56 Death 1 51.68 INFLAMMATION 1 36.64 Disease 16 34.16 Necrosis 2 27.36 Cancer 2 27.00 Infection 5 5.00 Arthritis 4 5.00 Experimental Arthritis 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

One of the most prominent T cell co-stimulatory signals is mediated through the CD28–CD80/86 pathway, which regulates interleukin-2 production and the expression of anti-apoptotic molecules, such as Bcl-xL [4,5].

CD80 Regulation (regulates) of Gene_expression (production) of interleukin-2 in T cell associated with apoptosis

1) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833980 Disease Relevance 0.43 Pain Relevance 0.11

General Comments

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