INT299783

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| style="color: black; background:#AAFCFB; white-space:wrap;"| '''Disease Relations:'''
 
| style="color: black; background:#AAFCFB; white-space:wrap;"| '''Disease Relations:'''
 
(frequency)
 
(frequency)
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[arthropathy]] (8)
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Arthropathy]] (8)
 
{{#icon: chilli.png|Quite High}}
 
{{#icon: chilli.png|Quite High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[INFLAMMATION]] (8)
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[INFLAMMATION]] (8)
 
{{#icon: chilli.png|Quite High}}
 
{{#icon: chilli.png|Quite High}}
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[apoptosis]] (12)
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Apoptosis]] (12)
 
{{#icon: chilli.png|Quite High}}
 
{{#icon: chilli.png|Quite High}}
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[death]] (6)
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Death]] (6)
 
{{#icon: chilli.png|Quite High}}
 
{{#icon: chilli.png|Quite High}}
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[demyelinating disease]] (6)
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Demyelinating Disease]] (6)
 
{{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 
{{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[necrosis]] (12)
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Necrosis]] (12)
 
{{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 
{{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[staphylococcus infection]] (6)
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Staphylococcus Infection]] (6)
 
{{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 
{{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[mycobacterial infection]] (2)
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Mycobacterial Infection]] (2)
 
{{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 
{{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 
|}
 
|}
|
+
{| cellpadding=3 cellspacing=0
mutations
+
|-
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Protein
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;" align="center"| Mutation
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;" align="center"| Frequency
 +
|-
 +
 
 +
|}
 
|-
 
|-
 
|}
 
|}

Revision as of 11:19, 12 September 2012

Context Info
Confidence 0.3651028500
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in NULL
Documents 7
Total Number 8

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd28)
Anatomy Mention Frequency
T cell 2
macrophages 1
B cells 1
dendritic cells 1
Cd28 (Mus musculus)
Cd80 (Mus musculus)
Pain Relations:

(frequency)

abatacept (242)

High High

Infliximab (2)

Quite High

Inflammation (8)

Quite High

Corticosteroids (12)

Very Low Very Low Very Low

methotrexate (42)

Very Low Very Low Very Low

cytokines (32)

Very Low Very Low Very Low

withdrawal (6)

Very Low Very Low Very Low

painful (6)

Very Low Very Low Very Low

Disease Relations:

(frequency)

Arthropathy (8)

Quite High

INFLAMMATION (8)

Quite High

Apoptosis (12)

Quite High

Death (6)

Quite High

Demyelinating Disease (6)

Very Low Very Low Very Low

Necrosis (12)

Very Low Very Low Very Low

Staphylococcus Infection (6)

Very Low Very Low Very Low

Mycobacterial Infection (2)

Very Low Very Low Very Low

Protein Mutation Frequency

Sentences Mentioned In

Key: Protein Event Anatomy Negation Speculation Pain term
In addition to the CD80/86-CD28 interaction, co-stimulation of T cell responses occurs through the CD40-CD154 interaction between APCs and T cells.
CD28 Binding (interaction) of CD80 in T cell
1) Confidence 0.140812717444618 Published 2010 Journal N/A Section N/A Doc Link PMC2875641
In addition to the CD80/86-CD28 interaction, co-stimulation of T cell responses occurs through the CD40-CD154 interaction between APCs and T cells.
CD28 Binding (interaction) of CD80 in T cell
2) Confidence 0.140812717444618 Published 2010 Journal N/A Section N/A Doc Link PMC2875641
These observations suggest that CD28–CD80/86 interactions are important in the initiation of the arthritis.
CD28 Binding (interactions) of CD80
3) Confidence 0.083477425726812 Published 2005 Journal N/A Section N/A Doc Link PMC2833980
These observations suggest that CD28–CD80/86 interactions are important in the initiation of the arthritis.
CD28 Binding (interactions) of CD80
4) Confidence 0.083477425726812 Published 2005 Journal N/A Section N/A Doc Link PMC2833980
The regulatory effects of interrupting CD28 interactions with CD80/86 have been harnessed in recombinant molecules (CTLA4–immunoglobulin [Ig]) that combine the extracellular domain of human CTLA4 with a portion of the Fc domain of IgG1 [10].
CD28 Binding (interactions) of CD80
5) Confidence 0.083477425726812 Published 2005 Journal N/A Section N/A Doc Link PMC2833980
CD28 is present on most T cells and it binds to both CD80 (B7-1) and CD86 (B7-2), which are present on antigen-presenting cells, including dendritic cells, B cells, and macrophages.
CD28 Binding (binds) of CD80 in dendritic cells
6) Confidence 0.083477425726812 Published 2005 Journal N/A Section N/A Doc Link PMC2833980
CD28 is present on most T cells and it binds to both CD80 (B7-1) and CD86 (B7-2), which are present on antigen-presenting cells, including dendritic cells, B cells, and macrophages.
CD28 Binding (binds) of CD80 in macrophages
7) Confidence 0.0283823247471161 Published 2005 Journal N/A Section N/A Doc Link PMC2833980
CD28 is present on most T cells and it binds to both CD80 (B7-1) and CD86 (B7-2), which are present on antigen-presenting cells, including dendritic cells, B cells, and macrophages.
CD28 Binding (binds) of CD80 in B cells
8) Confidence 0.0283823247471161 Published 2005 Journal N/A Section N/A Doc Link PMC2833980

General Comments

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